Last Updated: March 2026 · Medically Reviewed

Keto Diet Explained: Macros, Benefits, Risks (2026)

By Dr. Sarah Mitchell, M.D.·IndexBody Editorial Team
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What Is the Ketogenic Diet?

The ketogenic (keto) diet is a very low carbohydrate, high fat dietary approach that shifts the body into a metabolic state called ketosis. In ketosis, your liver converts fatty acids into ketone bodies (primarily beta-hydroxybutyrate, acetoacetate, and acetone), which become the primary fuel source for the brain and muscles instead of glucose.

Standard keto macros: approximately 70% of calories from fat, 25% from protein, and 5% from carbohydrates — typically 20–50g of net carbs per day (net carbs = total carbs minus dietary fibre).

The Clinical Evidence

Weight loss: Meta-analyses consistently show keto produces rapid initial weight loss (largely water and glycogen) followed by fat loss comparable to other calorie-restricted diets over 12 months. The 2022 Annual Review of Nutrition concluded that keto offers no meaningful metabolic advantage over other diets when calories and protein are equated.

Type 2 diabetes: Some of the strongest evidence for keto. Studies show meaningful reductions in HbA1c, fasting glucose, and insulin requirements in people with type 2 diabetes following keto. Some participants have achieved remission.

Epilepsy: The original medical application of keto, developed in the 1920s. Still used today for drug-resistant epilepsy, particularly in children, where it can reduce seizure frequency by 50% or more in approximately half of patients.

Benefits of the Keto Diet

Risks and Limitations

Frequently Asked Questions

How many carbs can I eat on keto?
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Most people need to stay below 20–50g of net carbs per day to maintain ketosis. Net carbs = total carbohydrates minus dietary fibre. Starting with 20g net carbs is the most conservative approach for reliably achieving ketosis.
How long does it take to enter ketosis?
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Most people enter ketosis within 2–4 days of restricting carbs below 50g net per day. Depleting liver glycogen stores is the primary prerequisite. Exercising while transitioning to keto can accelerate this by 12–24 hours.
Is keto safe long-term?
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Short to medium-term keto (up to 2 years) is well-tolerated by most healthy adults in research. Long-term data beyond 2 years is more limited. Regular monitoring of lipid panels is advisable, as some individuals see unfavourable LDL increases on high saturated fat keto diets.
SM
Written & Reviewed by Dr. Sarah Mitchell, M.D.
Board-Certified Internal Medicine · 12 Years Clinical Experience
Dr. Mitchell reviews all IndexBody health content for clinical accuracy and alignment with WHO, CDC, and NIH guidelines. All articles are updated annually.

References & Sources

  1. Bueno, N.B. et al. (2013). Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss. British Journal of Nutrition, 110(7), 1178–1187.
  2. Bolla, A.M. et al. (2019). Low-carb and ketogenic diets in type 1 and type 2 diabetes. Nutrients, 11(5), 962.
  3. Paoli, A. et al. (2013). Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate ketogenic diets. European Journal of Clinical Nutrition, 67(8), 789–796.